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Drugs, General

Could Sildenafil Increase Skin Cancer Risk?

Sildenafil, the active ingredient in Viagra, was originally developed to treat heart conditions, but during original trials it was found to be more effective at treating erectile dysfunction (also known as impotence).sildenafil

But now, scientists have warned that the drug could increase the risk of melanoma – the deadliest form of skin cancer.

Researchers at the University of Tübingen in Germany have discovered that Sildenafil can encourage tumors to grow more rapidly.

A recent study found that Sildenafil can stimulate skin cancer growth.

Sildenafil has a stimulating effect on the messenger molecule cyclic guanosine monophosphate (cGMP), which promotes the growth of existing malignant melanomas.

The scientist came to this conclusion through animal experiments and human cell cultures.

Cells normally contain an enzyme called phosphodiesterase type 5 (PDE5), that ensures the newly-formed cGMP is continuously broken down.

But, Sildenafil belongs to a group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors.

Study author Professor Robert Feil said: ‘Taking sildenafil basically disables this brake.’

Consequently, the melanoma begins to grow more aggressively.

However, the study noted that there is no reason for men to stop taking PDE5 inhibitors to treat erectile dysfunction.

The researchers also have to take into account that the possibility that a higher incidence of skin cancer may be due to lifestyles, including sunbathing on holiday.

Professor Feil warned: ‘Ultimately, we should all be thinking about reducing our risk of skin cancer and cutting our exposure time to the sun, as well as using effective UV protection.’

Sildenafil is marketed as Viagra and was approved by FDA (The Food and Drug Administration) on 27th March 1988. Pfizer’s patent on Sildenafil expired on 21 June 2013.

If you are concerned that Sildenafil (Viagra) could increase the risk of skin cancer then there is other alternative prescription only  medication for erectile dysfunction such as Cialis and Levitra.

For further information about Sildenafil (Viagra) and other erectile dysfunction medication, please go to www.ukmeds4u.com.

To read the full article, please click here.

 

Drugs, Erectile dysfunction

Could Cialis Be Effective In Treating Cancerous Tumours?

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cialis 20mgA clinical trial is underway which will hopefully show that Cialis weakens the ability of a tumour to fight the human immune system.

The trial is specifically focusing on those people suffering from tumours in the head and neck.

Professor Joseph Califano from the Department of Otolaryngology, Head and Neck Surgery at Johns Hopkins Hospital explained that a suppressed immune system could be the reason why these tumours respond so aggressively. He added that Cialis could prevent the immune system from producing nitric oxide which was being used by the tumours to create a shield to protect them.

It is hoped that Cialis will help the body to fight tumours on its own and cause them to shrink and possibly disappear.

Other research has already been done using Viagra for cancer treatment by Professor Ivan Borrello , a colleague of Dr. Califano. They have been working together on other studies using mice but reportedly prefer using Cialis because it works for longer period before wearing off.

One of the great advantages of using Cialis to treat head and neck tumours is that the drug is safe and its side effects are minimal.  In fact it was even noted that when compared to radiotherapy or chemotherapy the side effects of Cialis were significantly more pleasant!

Obviously the Cialis will not cure cancer alone but it could be used as a complementary treatment alongside standard cancer therapies.

Both men and women are being enrolled into the clinical trial which has been funded by the National Cancer Institute in America. It is hoped that the daily doses of Cialis over the two week trial period will boost the immune systems of the participants.

Dr. Califano mentioned that the male participants were very happy about the idea of being given Cialis as part of their treatment for cancer.

For more information about erectile dysfunction or prescription only medicine such as Cialis, please go to: www.ukmeds4u.com